E3 Ligand-Linker Conjugate 9( —— )

Catalog No. M13069 CAS No. 1957236-20-2

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Product Name

E3 Ligand-Linker Conjugate 9
Note

Research use only, not for human use.
Brief Description

An E3 ligase ligand-linker conjugate for PROTAC.
Description

An E3 ligase ligand-linker conjugate for PROTAC.
In Vitro

Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is composed of Degron (E3 ubiquitin ligase) and a linker, and they are used in PROTAC technology. Thalidomide-O-amido-PEG3-C2-NH2 binds to the targeting ligand to induce the target protein (including BRD4, BRD2, and BRD3) degradation.
In Vivo

——
Synonyms

——
Pathway

PROTACs
Target

E3 Ligase Ligand
Recptor

E3 Ligase Ligand
Research Area

Other Indications
Indication

——

CAS Number

1957236-20-2
Formula Weight

506.512
Molecular Formula

C23H30N4O9
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCOCCN
Chemical Name

N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

1. Lohbeck J, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262.

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